Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(S)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester

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Chemical Name:Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(S)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester
CAS No.:779358-70-2
Molecular Formula:C₂₆H₃₁NO₆
Molecular Weight:453.535
Hs Code.:

Synonyms:Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(S)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester

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Chemical Property of Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(S)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester

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Technology Process of Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(S)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester

There total 4 articles about Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(S)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 75-16-1
methylmagnesium bromide

: 779358-69-9
Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(E)-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propenyl]-phenyl ester

: 779358-70-2
Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(S)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester

: Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(R)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester

Guidance literature:: With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; diethyl ether; at 0 ℃;
DOI:10.1016/j.bmcl.2004.06.077

Reference yield:

: 99395-88-7,7480-32-2
(S)-4-phenyl-2-oxazolidinone

: 779358-70-2
Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(S)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: PvCl; Et₃N / tetrahydrofuran / -78 - 0 °C

1.2: 70 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

2.1: 55 percent / CuBr*Me₂S / tetrahydrofuran; diethyl ether / 0 °C

With copper(I) bromide dimethylsulfide complex; pivaloyl chloride; triethylamine; In tetrahydrofuran; diethyl ether; 2.1: Michael addition;
DOI:10.1016/j.bmcl.2004.06.077

Reference yield:

: 332186-71-7
Methyl (E)-3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)-2-propenoate

: 779358-70-2
Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(S)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 81 percent / aq. NaOH / tetrahydrofuran

2.1: PvCl; Et₃N / tetrahydrofuran / -78 - 0 °C

2.2: 70 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

3.1: 55 percent / CuBr*Me₂S / tetrahydrofuran; diethyl ether / 0 °C

With sodium hydroxide; copper(I) bromide dimethylsulfide complex; pivaloyl chloride; triethylamine; In tetrahydrofuran; diethyl ether; 3.1: Michael addition;
DOI:10.1016/j.bmcl.2004.06.077