Technology Process of (Z)-3-(2,6-dicyanophenyl)-2-(prop-2-ynyloxy)-N-m-tolylacrylamide
There total 5 articles about (Z)-3-(2,6-dicyanophenyl)-2-(prop-2-ynyloxy)-N-m-tolylacrylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
dichloromethane;
for 1h;
Inert atmosphere;
DOI:10.1016/j.tet.2011.05.067
- Guidance literature:
-
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Inert atmosphere
2: sodium hydrogencarbonate / dichloromethane / 1 h / Inert atmosphere
With
oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide;
In
dichloromethane;
DOI:10.1016/j.tet.2011.05.067
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tributylphosphine; diethylazodicarboxylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere
2.2: pH 4 - 5
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Inert atmosphere
4.1: sodium hydrogencarbonate / dichloromethane / 1 h / Inert atmosphere
With
oxalyl dichloride; lithium hydroxide monohydrate; tributylphosphine; sodium hydrogencarbonate; N,N-dimethyl-formamide; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; water;
1.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.05.067
