N-allyl-1-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine

Base Information

Chemical Name:N-allyl-1-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine
CAS No.:1399347-20-6
Molecular Formula:C₂₄H₂₉NO₄
Molecular Weight:395.499
Hs Code.:

Synonyms:N-allyl-1-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-allyl-1-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine

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Technology Process of N-allyl-1-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine

There total 3 articles about N-allyl-1-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 627-37-2
N-methyl-N-allylamine

: 5320-31-0
3,4,5-trimethoxyphenylacetaldehyde

: 768-60-5
4-methoxyphenylacetylen

: 1399347-20-6
N-allyl-1-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine

Guidance literature:: With copper(I) bromide; In toluene; at 100 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.mcat.2018.06.007

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 1399347-20-6
N-allyl-1-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

3.1: copper(I) bromide / toluene / 1 h / 100 °C / Microwave irradiation; Inert atmosphere

With potassium tert-butylate; trifluoroacetic acid; copper(I) bromide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/chem.201700934

Reference yield:

: 182217-53-4
1,2,3-trimethoxy-5-(2-methoxyvinyl)benzene

: 1399347-20-6
N-allyl-1-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane; water / 12 h / 20 °C

2: copper(I) bromide / toluene / 1 h / 100 °C / Microwave irradiation

With trifluoroacetic acid; copper(I) bromide; In dichloromethane; water; toluene;
DOI:10.1016/j.mcat.2018.06.007