1-(3-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-3-phenyl-pyrrolidin-1-yl)-ethanone

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Chemical Name:1-(3-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-3-phenyl-pyrrolidin-1-yl)-ethanone
CAS No.:1014701-37-1
Molecular Formula:C₂₇H₃₅N₅O₂
Molecular Weight:461.607
Hs Code.:

Synonyms:1-(3-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-3-phenyl-pyrrolidin-1-yl)-ethanone

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Chemical Property of 1-(3-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-3-phenyl-pyrrolidin-1-yl)-ethanone

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Technology Process of 1-(3-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-3-phenyl-pyrrolidin-1-yl)-ethanone

There total 10 articles about 1-(3-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-3-phenyl-pyrrolidin-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: C₂₅H₃₃N₅O*7ClH

: 108-24-7
acetic anhydride

: 1014701-37-1
1-(3-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-3-phenyl-pyrrolidin-1-yl)-ethanone

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 1014702-81-8
(5-benzyl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

: 1014701-37-1
1-(3-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-3-phenyl-pyrrolidin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium formate / palladium on activated charcoal / methanol / 8 h / Heating / reflux

2: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 40 °C

4: pyridine / dichloromethane / 72 h / 20 °C

With pyridine; hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 192940-81-1,209667-56-1
1-(t-butoxycarbonyl)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine

: 1014701-37-1
1-(3-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-3-phenyl-pyrrolidin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hypochlorite; sodium hydrogencarbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 4 h / 0 - 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 40 °C

4: pyridine / dichloromethane / 72 h / 20 °C

With pyridine; hydrogenchloride; sodium hypochlorite; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In 1,4-dioxane; methanol; dichloromethane; water;