potassium 5-amino-1-phenyl-1H-pyrazole-4-carboxylate

Base Information

• Chemical Name: potassium 5-amino-1-phenyl-1H-pyrazole-4-carboxylate
• CAS No.: 111423-15-5
• Molecular Formula: C₁₀H₈N₃O₂*K
• Molecular Weight: 241.291
• Mol file: 111423-15-5.mol

Synonyms:potassium 5-amino-1-phenyl-1H-pyrazole-4-carboxylate

Chemical Property of potassium 5-amino-1-phenyl-1H-pyrazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of potassium 5-amino-1-phenyl-1H-pyrazole-4-carboxylate

There total 2 articles about potassium 5-amino-1-phenyl-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate (16078-71-0) → potassium 5-amino-1-phenyl-1H-pyrazole-4-carboxylate (111423-15-5)

Guidance literature:

With potassium hydroxide; In isopropyl alcohol; at 70 ℃; for 3h;

DOI:10.1021/ol4023722

Reference yield:

phenylhydrazine (100-63-0) → potassium 5-amino-1-phenyl-1H-pyrazole-4-carboxylate (111423-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / water / 12 h / 20 °C

2: potassium hydroxide / isopropyl alcohol / 3 h / 70 °C

With acetic acid; potassium hydroxide; In water; isopropyl alcohol;

DOI:10.1021/ol4023722

Reference yield: 90.0%

potassium 5-amino-1-phenyl-1H-pyrazole-4-carboxylate (111423-15-5) + ortho-bromobenzaldehyde (6630-33-7) → 3-phenyl-3H-pyrazolo[3,4-c]isoquinoline

Guidance literature:

With copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; 1,10-Phenanthroline; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 160 ℃; for 0.25h; Reagent/catalyst; Microwave irradiation; Molecular sieve;

DOI:10.1021/ol4023722

upstream raw materials:

ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate

phenylhydrazine

Downstream raw materials:

1,5-diphenyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione

1-phenyl-5-p-tolyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione

1-Phenyl-6-p-tolylamino-1H-pyrazolo[3,4-d][1,3]oxazin-4-one

6-(4-Chloro-phenylamino)-1-phenyl-1H-pyrazolo[3,4-d][1,3]oxazin-4-one