4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime

Base Information

• Chemical Name: 4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime
• CAS No.: 150772-84-2
• Molecular Formula: C₁₆H₁₄F₃NO₅S₂
• Molecular Weight: 421.418
• Mol file: 150772-84-2.mol

Synonyms:4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime

Chemical Property of 4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime

There total 3 articles about 4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime tosylate (150772-83-1) → 4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime (150772-84-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Ambient temperature;

DOI:10.1021/ja00071a017

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime (150772-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 82 percent / 3-chloroperoxybenzoic acid (m-CPBA) / CH₂Cl₂ / Ambient temperature

With pyridine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/ja00071a017

Reference yield:

2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime (253585-96-5) → 4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime (150772-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 82 percent / 3-chloroperoxybenzoic acid (m-CPBA) / CH₂Cl₂ / Ambient temperature

With pyridine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/ja00071a017

upstream raw materials:

2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime tosylate

p-toluenesulfonyl chloride

2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime

Downstream raw materials:

3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine