Ethanone, 2,2,2-trifluoro-1-[4-(methylthio)phenyl]-, oxime

Base Information

• Chemical Name: Ethanone, 2,2,2-trifluoro-1-[4-(methylthio)phenyl]-, oxime
• CAS No.: 253585-96-5
• Molecular Formula: C9H8F3NOS
• Molecular Weight: 235.23
• Mol file: 253585-96-5.mol

Synonyms:

Chemical Property of Ethanone, 2,2,2-trifluoro-1-[4-(methylthio)phenyl]-, oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 2,2,2-trifluoro-1-[4-(methylthio)phenyl]-, oxime

There total 1 articles about Ethanone, 2,2,2-trifluoro-1-[4-(methylthio)phenyl]-, oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2,2-trifluoro-1-(4-methylsulfanyl-phenyl)-ethanone (122243-33-8) → 2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime (253585-96-5)

Guidance literature:

With hydroxylamine hydrochloride; In pyridine; ethanol; for 3h; Heating;

DOI:10.1055/s-1995-3956

Reference yield: 96.0%

p-toluenesulfonyl chloride (98-59-9) + 2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime (253585-96-5) → 2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime tosylate (150772-83-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1055/s-1995-3956

Reference yield:

2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime (253585-96-5) → 3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diazirine

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 82 percent / 3-chloroperoxybenzoic acid (m-CPBA) / CH₂Cl₂ / Ambient temperature

3: 95 percent / NH₃(liq.) / diethyl ether / 12 h / Ambient temperature

4: 92 percent / MnO₂ / diethyl ether / 1 h / 0 °C

With pyridine; manganese(IV) oxide; ammonia; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane;

DOI:10.1021/ja00071a017

upstream raw materials:

2,2,2-trifluoro-1-(4-methylsulfanyl-phenyl)-ethanone

Downstream raw materials:

2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime tosylate

3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine

4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime

Refernces