3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine

Base Information

• Chemical Name: 3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine
• CAS No.: 150772-85-3
• Molecular Formula: C₉H₉F₃N₂O₂S
• Molecular Weight: 266.244
• Mol file: 150772-85-3.mol

Synonyms:3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine

Chemical Property of 3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine

There total 3 articles about 3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime (150772-84-2) → 3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine (150772-85-3)

Guidance literature:

With ammonia; In diethyl ether; for 12h; Ambient temperature;

DOI:10.1021/ja00071a017

Reference yield:

2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime (253585-96-5) → 3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine (150772-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 82 percent / 3-chloroperoxybenzoic acid (m-CPBA) / CH₂Cl₂ / Ambient temperature

3: 95 percent / NH₃(liq.) / diethyl ether / 12 h / Ambient temperature

With pyridine; ammonia; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane;

DOI:10.1021/ja00071a017

Reference yield:

2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime tosylate (150772-83-1) → 3-(trifluoromethyl)-3-(4-(methylsulfonyl)phenyl)diaziridine (150772-85-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / 3-chloroperoxybenzoic acid (m-CPBA) / CH₂Cl₂ / Ambient temperature

2: 95 percent / NH₃(liq.) / diethyl ether / 12 h / Ambient temperature

With ammonia; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane;

DOI:10.1021/ja00071a017

upstream raw materials:

4-(methylsulfonyl)trifluoroacetophenone O-(p-toluenesulfonyl)oxime

2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime

2,2,2-trifluoro-1-(4-methylsulfanylphenyl)ethanone oxime tosylate

Refernces