3-acetyl-8-methoxy-chromen-2-one

Base Information

• Chemical Name: 3-acetyl-8-methoxy-chromen-2-one
• CAS No.: 5452-39-1
• Molecular Formula: C12H10O4
• Molecular Weight: 218.209
• Hs Code.: 2932209090
• Mol file: 5452-39-1.mol

Synonyms:8-Methoxy-3-acetylcoumarin;3-acetyl-8-methoxy-2H-chromen-2-one;3-Acetyl-8-methoxy-cumarin;2h-1-benzopyran-2-one,3-acetyl-8-methoxy;3-acetyl-8-methoxy-2H-1-benzopyran-2-one;3-acetyl-8-methoxycoumarin;

Chemical Property of 3-acetyl-8-methoxy-chromen-2-one

Chemical Property:

• Vapor Pressure: 6.3E-08mmHg at 25°C
• Boiling Point: 439.6°C at 760 mmHg
• Flash Point: 200.5°C
• PSA: 56.51000
• Density: 1.281g/cm³
• LogP: 2.00420

Purity/Quality:

3-Acetyl-8-methoxy-2H-chromen-2-one ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-acetyl-8-methoxy-chromen-2-one

There total 10 articles about 3-acetyl-8-methoxy-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl acetoacetate (141-97-9) + 3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 3-acetyl-8-methoxy-2H-chromen-2-one (5452-39-1)

Guidance literature:

With piperidine; at 20 ℃; for 0.0833333h;

DOI:10.1246/cl.2001.110

Reference yield: 92.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + acetoacetic acid methyl ester (105-45-3) → 3-acetyl-8-methoxy-2H-chromen-2-one (5452-39-1)

Guidance literature:

With 6% sodium alginate-13% morpholine-water gel-entrapped (Ca²⁺) base catalyst; In methanol; at 27 - 30 ℃; for 1h;

DOI:10.1039/c7nj02342a

Reference yield: 90.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + N-phenylacetoacetamide (102-01-2,98624-45-4) → 3-acetyl-8-methoxy-2H-chromen-2-one (5452-39-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1039/c7nj00980a

upstream raw materials:

ethyl acetoacetate

3-methoxy-2-hydroxybenzaldehyde

2-hydroxy-3-methoxybenzylideneimine

acetoacetic acid methyl ester

Downstream raw materials:

C₂₀H₁₉N₃O₄S

3-[2-(3,5-Dimethyl-4-phenylazo-pyrazol-1-yl)-thiazol-4-yl]-8-methoxy-chromen-2-one

propionic acid N'-[4-(8-methoxy-2-oxo-2H-chromen-3-yl)-thiazol-2-yl]-hydrazide

8-Methoxy-3-(2-phenyl-thiazol-4-yl)-chromen-2-one