2-(acetylamino)-6-(diphenylcarbamoyl)-9-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-9H-purine

Base Information

Chemical Name:2-(acetylamino)-6-(diphenylcarbamoyl)-9-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-9H-purine
CAS No.:1257309-85-5
Molecular Formula:C₃₆H₄₃N₇O₈
Molecular Weight:701.78
Hs Code.:

Synonyms:2-(acetylamino)-6-(diphenylcarbamoyl)-9-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-9H-purine

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Chemical Property of 2-(acetylamino)-6-(diphenylcarbamoyl)-9-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-9H-purine

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Technology Process of 2-(acetylamino)-6-(diphenylcarbamoyl)-9-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-9H-purine

There total 3 articles about 2-(acetylamino)-6-(diphenylcarbamoyl)-9-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: N-(1,3-dipivaloyloxyprop-2-yl)-N-(pivaloyloxymethyl)acetamide

: 112233-74-6
N₂-acetyl-O₆-(diphenylcarbamoyl)guanine

: 1257309-85-5
2-(acetylamino)-6-(diphenylcarbamoyl)-9-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-9H-purine

Guidance literature:: N₂-acetyl-O₆-(diphenylcarbamoyl)guanine; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; at 80 ℃; for 0.25h; Inert atmosphere; Sealed tube;

N-(1,3-dipivaloyloxyprop-2-yl)-N-(pivaloyloxymethyl)acetamide; With trimethylsilyl trifluoromethanesulfonate; In toluene; at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1080/15257770.2010.519367

Reference yield:

: O,O'-dipivaloylserinol hydrochloride

: 1257309-85-5
2-(acetylamino)-6-(diphenylcarbamoyl)-9-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 24 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 96 h / 20 °C / Cooling with ice

3.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 0.25 h / 80 °C / Inert atmosphere; Sealed tube

3.2: 1 h / 80 °C / Inert atmosphere

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1080/15257770.2010.519367

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1257309-85-5
2-(acetylamino)-6-(diphenylcarbamoyl)-9-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-9H-purine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4 h / 90 °C

2.1: pyridine / 24 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3.2: 96 h / 20 °C / Cooling with ice

4.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 0.25 h / 80 °C / Inert atmosphere; Sealed tube

4.2: 1 h / 80 °C / Inert atmosphere

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1080/15257770.2010.519367