2-(2-chloro-4-(2,4-dibromophenyl)thiazol-5-ylthio)-N-(2-chloropyridin-3-yl)acetamide

Base Information

Chemical Name:2-(2-chloro-4-(2,4-dibromophenyl)thiazol-5-ylthio)-N-(2-chloropyridin-3-yl)acetamide
CAS No.:1260403-14-2
Molecular Formula:C₁₆H₉Br₂Cl₂N₃OS₂
Molecular Weight:554.113
Hs Code.:

Synonyms:2-(2-chloro-4-(2,4-dibromophenyl)thiazol-5-ylthio)-N-(2-chloropyridin-3-yl)acetamide

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Chemical Property of 2-(2-chloro-4-(2,4-dibromophenyl)thiazol-5-ylthio)-N-(2-chloropyridin-3-yl)acetamide

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Technology Process of 2-(2-chloro-4-(2,4-dibromophenyl)thiazol-5-ylthio)-N-(2-chloropyridin-3-yl)acetamide

There total 6 articles about 2-(2-chloro-4-(2,4-dibromophenyl)thiazol-5-ylthio)-N-(2-chloropyridin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.8%

: 1260403-04-0
2-(2-amino-4-(2,4-dibromophenyl)thiazol-5-ylthio)-N-(2-chloropyridin-3-yl)acetamide

: 1260403-14-2
2-(2-chloro-4-(2,4-dibromophenyl)thiazol-5-ylthio)-N-(2-chloropyridin-3-yl)acetamide

Guidance literature:: With tert.-butylnitrite; copper(l) chloride; In acetonitrile; at 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1007/s12272-012-0604-y

Reference yield:

: 1385770-66-0
C₁₂H₁₁Br₃O₃S

: 1260403-14-2
2-(2-chloro-4-(2,4-dibromophenyl)thiazol-5-ylthio)-N-(2-chloropyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 20 °C

2: sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

3: phosphorus pentachloride / diethyl ether / 5 h / 20 °C

4: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

5: tert.-butylnitrite; copper(l) chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere

With tert.-butylnitrite; phosphorus pentachloride; triethylamine; copper(l) chloride; sodium hydroxide; In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile; 5: Sandmeyer reaction;
DOI:10.1007/s12272-012-0604-y

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1260403-14-2
2-(2-chloro-4-(2,4-dibromophenyl)thiazol-5-ylthio)-N-(2-chloropyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: aluminum (III) chloride / 20 - 65 °C

2: sodium carbonate / ethanol / 12 h / 20 °C

3: bromine / acetic acid / 8.5 h / 20 °C

4: ethanol / 20 °C

5: sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

6: phosphorus pentachloride / diethyl ether / 5 h / 20 °C

7: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

8: tert.-butylnitrite; copper(l) chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; tert.-butylnitrite; phosphorus pentachloride; bromine; sodium carbonate; triethylamine; copper(l) chloride; sodium hydroxide; In diethyl ether; ethanol; dichloromethane; acetic acid; dimethyl sulfoxide; acetonitrile; 1: Friedel Crafts reaction / 8: Sandmeyer reaction;
DOI:10.1007/s12272-012-0604-y