N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester

Base Information

• Chemical Name: N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester
• CAS No.: 852853-12-4
• Molecular Formula: C₂₂H₃₄N₄O₈S
• Molecular Weight: 514.6
• Mol file: 852853-12-4.mol

Synonyms:N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester

Chemical Property of N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester

There total 7 articles about N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-(N-methyl-N-nosyl-L-isoleucyl)-L-alanine methyl ester (852853-06-6) + Nα-nosyl-L-valine chloride (852853-21-5) → N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester (852853-12-4)

Guidance literature:

N-(N-methyl-N-nosyl-L-isoleucyl)-L-alanine methyl ester; With sodium methylate; mercaptoacetic acid; In methanol; acetonitrile; at 50 ℃; for 1h;

N^α-nosyl-L-valine chloride; With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 0.75h; pH=8;

DOI:10.1021/jo0478959

Reference yield:

N-nosyl-L-isoleucine chloride (852853-20-4) → N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester (852853-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 94 percent / NaHCO₃ / CHCl₃; H₂O / 0.75 h / 20 °C

2.1: 100 percent / diethyl ether; CH₂Cl₂ / 0.5 h / 20 °C

3.1: mercaptoacetic acid; sodium methoxide / acetonitrile; methanol / 1 h / 50 °C

3.2: 72 percent / NaHCO₃ / CH₂Cl₂ / 0.75 h / 20 °C / pH 8

With sodium methylate; sodium hydrogencarbonate; mercaptoacetic acid; In methanol; diethyl ether; dichloromethane; chloroform; water; acetonitrile;

DOI:10.1021/jo0478959

Reference yield:

3-methyl-2-(4-nitrophenylsulphonamido)pentanoic acid (852852-81-4) → N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester (852853-12-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / CH₂Cl₂ / 0.5 h / Heating

2.1: 94 percent / NaHCO₃ / CHCl₃; H₂O / 0.75 h / 20 °C

3.1: 100 percent / diethyl ether; CH₂Cl₂ / 0.5 h / 20 °C

4.1: mercaptoacetic acid; sodium methoxide / acetonitrile; methanol / 1 h / 50 °C

4.2: 72 percent / NaHCO₃ / CH₂Cl₂ / 0.75 h / 20 °C / pH 8

With thionyl chloride; sodium methylate; sodium hydrogencarbonate; mercaptoacetic acid; In methanol; diethyl ether; dichloromethane; chloroform; water; acetonitrile;

DOI:10.1021/jo0478959

upstream raw materials:

N-(N-methyl-N-nosyl-L-isoleucyl)-L-alanine methyl ester

N^α-nosyl-L-valine chloride

N-nosyl-L-isoleucine chloride

3-methyl-2-(4-nitrophenylsulphonamido)pentanoic acid