N-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide

Base Information

Chemical Name:N-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide
CAS No.:849145-47-7
Molecular Formula:C₂₀H₁₈F₂N₄O₂S
Molecular Weight:416.451
Hs Code.:

<i>N</i>-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide

Synonyms:N-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide

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Chemical Property of N-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide

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Technology Process of N-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide

There total 1 articles about N-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 849145-46-6
N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-[4-(4-nitrophenyl)]thiazol-2-ylamine

: 849145-47-7
N-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide

Guidance literature:: With iron; ammonium chloride; In ethanol; for 16h; Heating;
DOI:10.1039/b415090b

Reference yield: 48.0%

: 849145-47-7
N-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide

: 20260-53-1
pyridine-3-carbonyl chloride hydrochloride

: 849145-48-8
N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-{4-[4-(N-pyridyl-3-carbonyl)aminophenyl]}thiazol-2-ylamine

Guidance literature:: With pyridine; for 18h; Heating;
DOI:10.1039/b415090b

Reference yield:

: 849145-47-7
N-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide

: 1-Methyl-1,4-dihydro-pyridine-3-carboxylic acid [4-(2-{(S)-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionylamino}-thiazol-4-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / pyridine / 18 h / Heating

2: 81 percent / dimethylformamide / 16 h / 20 °C

3: 31 percent / aq. Na₂CO₃; Na₂S₂O₄ / methanol / 4 h / 20 °C

With pyridine; sodium dithionite; sodium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/b415090b