(R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol

Base Information

Chemical Name:(R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol
CAS No.:176589-72-3
Molecular Formula:C₁₈H₂₂ClNO₂
Molecular Weight:319.831
Hs Code.:

Synonyms:(R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol

Suppliers and Price of (R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol

Chemical Property:

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Technology Process of (R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol

There total 1 articles about (R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58993-79-6,23239-32-9
(R)-(-)-p-methoxyamphetamine

: 20697-04-5,53631-04-2,115648-90-3,62600-71-9
(R)-meta-chlorostyrene oxide

: 176589-72-3
(R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol

Guidance literature:: With hydrogenchloride; N-Trimethylsilylacetamide; Yield given. Multistep reaction; 1.) 110 deg C, 2.) EtOAc, 0 deg C to room temp.;
DOI:10.1016/S0960-894X(97)00266-7

Reference yield: 90.0%

: 530-62-1
1,1'-carbonyldiimidazole

: 176589-72-3
(R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol

: 176495-21-9
(R)-5-(3-Chloro-phenyl)-3-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one

Guidance literature:: With triethylamine; In chloroform; Ambient temperature;
DOI:10.1016/S0960-894X(97)00266-7

Reference yield:

: 176589-72-3
(R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol

: 2-(4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / CHCl₃ / Ambient temperature

2: 81 percent / BBr₃ / CH₂Cl₂ / 0 °C

3: Na₂CO₃ / acetone / Ambient temperature

With boron tribromide; sodium carbonate; triethylamine; In dichloromethane; chloroform; acetone;
DOI:10.1016/S0960-894X(97)00266-7