methyl (2E)-3-[6-bromo-2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazin-8-yl]acrylate

Base Information

Chemical Name:methyl (2E)-3-[6-bromo-2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazin-8-yl]acrylate
CAS No.:1402609-47-5
Molecular Formula:C₃₁H₃₁BrN₄O₄
Molecular Weight:603.516
Hs Code.:

Synonyms:methyl (2E)-3-[6-bromo-2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazin-8-yl]acrylate

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Chemical Property of methyl (2E)-3-[6-bromo-2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazin-8-yl]acrylate

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Technology Process of methyl (2E)-3-[6-bromo-2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazin-8-yl]acrylate

There total 3 articles about methyl (2E)-3-[6-bromo-2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazin-8-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402608-82-5
tert-butyl (1-{4-[3-phenyl-6,8-dibromoimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1402609-47-5
methyl (2E)-3-[6-bromo-2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazin-8-yl]acrylate

Guidance literature:: With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In acetonitrile; at 150 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1402609-47-5
methyl (2E)-3-[6-bromo-2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazin-8-yl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / Reflux

3: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With pyridinium hydrobromide perbromide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; isopropyl alcohol; acetonitrile;

Reference yield:

: 1355999-71-1
tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1402609-47-5
methyl (2E)-3-[6-bromo-2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazin-8-yl]acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / Reflux

2: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; tris-(o-tolyl)phosphine; In isopropyl alcohol; acetonitrile;