1-(4-bromo-3-fluorophenyl)-2,2-dihydroxyethanone

Base Information

• Chemical Name: 1-(4-bromo-3-fluorophenyl)-2,2-dihydroxyethanone
• CAS No.: 1006875-89-3
• Molecular Formula: C₈H₆BrFO₃
• Molecular Weight: 249.036
• Mol file: 1006875-89-3.mol

Synonyms:1-(4-bromo-3-fluorophenyl)-2,2-dihydroxyethanone

Chemical Property of 1-(4-bromo-3-fluorophenyl)-2,2-dihydroxyethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-bromo-3-fluorophenyl)-2,2-dihydroxyethanone

There total 5 articles about 1-(4-bromo-3-fluorophenyl)-2,2-dihydroxyethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-bromo-3-fluorophenyl)ethan-1-one (304445-49-6) → 1-(4-bromo-3-fluorophenyl)-2,2-dihydroxyethanone (1006875-89-3) + 2-(4-bromo-3-fluorophenyl)-2-oxoacetaldehyde (1029714-83-7)

Guidance literature:

With hydrogen bromide; dimethyl sulfoxide; In water; at 60 ℃;

Reference yield:

1-(4-bromo-3-fluorophenyl)ethan-1-one (304445-49-6) → 1-(4-bromo-3-fluorophenyl)-2,2-dihydroxyethanone (1006875-89-3)

Guidance literature:

With water; hydrogen bromide; In dimethyl sulfoxide; at 60 ℃;

Reference yield:

4-bromo-3-fluorobenzoic acid (153556-42-4) → 1-(4-bromo-3-fluorophenyl)-2,2-dihydroxyethanone (1006875-89-3) + 2-(4-bromo-3-fluorophenyl)-2-oxoacetaldehyde (1029714-83-7)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: potassium carbonate / dichloromethane; water / 2 h / 20 °C

3: tetrahydrofuran / 1 h / 0 °C

4: water; hydrogen bromide / dimethyl sulfoxide / 60 °C

With oxalyl dichloride; water; hydrogen bromide; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

1-(4-bromo-3-fluorophenyl)ethan-1-one

4-bromo-3-fluorobenzoic acid

4-bromo-3-fluoro-N-methoxy-N-methyl-benzamide

4-bromo-3-fluorobenzoyl chloride

Downstream raw materials:

1-(4-bromo-3-fluorophenyl)-2,2-diethoxyethanone