(2-Amino-phenyl)-((3S,4S)-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-methanone

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Chemical Name:(2-Amino-phenyl)-((3S,4S)-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-methanone
CAS No.:159180-55-9
Molecular Formula:C₁₅H₂₂N₂O₅
Molecular Weight:310.35
Hs Code.:

Synonyms:(2-Amino-phenyl)-((3S,4S)-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-methanone

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Chemical Property of (2-Amino-phenyl)-((3S,4S)-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-methanone

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Technology Process of (2-Amino-phenyl)-((3S,4S)-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-methanone

There total 2 articles about (2-Amino-phenyl)-((3S,4S)-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 118-48-9
isatoic anhydride

: 138051-80-6
(3S,4S)-3,4-Bis(methoxymethoxy)pyrrolidine

: 159180-55-9
(2-Amino-phenyl)-((3S,4S)-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-methanone

Guidance literature:: With dmap; In N,N-dimethyl-formamide; 0 deg C -> room temp.;
DOI:10.1016/S0040-4039(00)78191-3

Reference yield:

: 137945-72-3
(3S,4S)-1-Benzyl-3,4-bis(methoxymethoxy)pyrrolidine

: 159180-55-9
(2-Amino-phenyl)-((3S,4S)-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd(OH)2-C / methanol / 3 h / 760 Torr / Ambient temperature

2: 4.4 g / DMAP / dimethylformamide / 1) 0 deg C -> room temperature, 2) room temperature, 15 h

With dmap; hydrogen; palladium hydroxide - carbon; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo961529a

Reference yield: 73.0%

: 67-56-1
methanol

: 159180-55-9
(2-Amino-phenyl)-((3S,4S)-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-methanone

: ((3R,4S)-2-Methoxy-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-phenyl-methanone

Guidance literature:: With hydrogenchloride; copper(l) chloride; sodium nitrite; In water; for 2h; Ambient temperature;
DOI:10.1016/S0040-4039(00)78191-3