(S)-benzyl 3-((S)-3-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(2,3-bis(benzyloxy)benzamido)propanoate

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Chemical Name:(S)-benzyl 3-((S)-3-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(2,3-bis(benzyloxy)benzamido)propanoate
CAS No.:1262890-84-5
Molecular Formula:C₅₄H₆₁N₃O₁₄
Molecular Weight:976.09
Hs Code.:

(S)-benzyl 3-((S)-3-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(2,3-bis(benzyloxy)benzamido)propanoate

Synonyms:(S)-benzyl 3-((S)-3-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(2,3-bis(benzyloxy)benzamido)propanoate

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Chemical Property of (S)-benzyl 3-((S)-3-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(2,3-bis(benzyloxy)benzamido)propanoate

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Technology Process of (S)-benzyl 3-((S)-3-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(2,3-bis(benzyloxy)benzamido)propanoate

There total 6 articles about (S)-benzyl 3-((S)-3-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(2,3-bis(benzyloxy)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262890-80-1
(S)-benzyl 2-(2,3-bis(benzyloxy)benzamido)-3-hydroxypropanoate

: 78088-98-9
(6S,10S)-10-(benzyloxymethyl)-2,2,14,14-tetramethyl-4,9,12-trioxo-3,8,13-trioxa-5,11-diazapentadecane-6-carboxylic acid

: 1262890-84-5
(S)-benzyl 3-((S)-3-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(2,3-bis(benzyloxy)benzamido)propanoate

Guidance literature:: (S)-benzyl 2-(2,3-bis(benzyloxy)benzamido)-3-hydroxypropanoate; (6S,10S)-10-(benzyloxymethyl)-2,2,14,14-tetramethyl-4,9,12-trioxo-3,8,13-trioxa-5,11-diazapentadecane-6-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 0 - 20 ℃; for 2h; Inert atmosphere;

With pyridine; In acetonitrile; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.tet.2010.11.007

Reference yield:

: 60022-62-0,879278-55-4,151651-44-4
L-serine benzyl ester hydrochloride

: 1262890-84-5
(S)-benzyl 3-((S)-3-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(2,3-bis(benzyloxy)benzamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2010.11.007

Reference yield:

: 74272-78-9
2,3-dibenzyloxybenzoic acid

: 1262890-84-5
(S)-benzyl 3-((S)-3-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(tert-butoxycarbonylamino)propanoyloxy)-2-(2,3-bis(benzyloxy)benzamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2010.11.007