3-Phenyl-thiopropionic acid S-[(R)-2-(dimethoxy-phosphoryloxy)-1-hexyloxymethyl-ethyl] ester

Base Information

Chemical Name:3-Phenyl-thiopropionic acid S-[(R)-2-(dimethoxy-phosphoryloxy)-1-hexyloxymethyl-ethyl] ester
CAS No.:1027591-49-6
Molecular Formula:C₂₀H₃₃O₆PS
Molecular Weight:432.518
Hs Code.:

Synonyms:3-Phenyl-thiopropionic acid S-[(R)-2-(dimethoxy-phosphoryloxy)-1-hexyloxymethyl-ethyl] ester

Suppliers and Price of 3-Phenyl-thiopropionic acid S-[(R)-2-(dimethoxy-phosphoryloxy)-1-hexyloxymethyl-ethyl] ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Phenyl-thiopropionic acid S-[(R)-2-(dimethoxy-phosphoryloxy)-1-hexyloxymethyl-ethyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-Phenyl-thiopropionic acid S-[(R)-2-(dimethoxy-phosphoryloxy)-1-hexyloxymethyl-ethyl] ester

There total 9 articles about 3-Phenyl-thiopropionic acid S-[(R)-2-(dimethoxy-phosphoryloxy)-1-hexyloxymethyl-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111-25-1
1-bromo-hexane

: 1027591-49-6
3-Phenyl-thiopropionic acid S-[(R)-2-(dimethoxy-phosphoryloxy)-1-hexyloxymethyl-ethyl] ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 25 deg C, 14 h

2: 100 percent / 1 N HCl / methanol / 24 h / 25 °C

3: 92 percent / pyridine / tetrahydrofuran / 14 h / 25 °C

4: 71 percent / pyridine / CH₂Cl₂ / 14 h / 25 °C

5: 70 percent / dimethylformamide / 16 h / 80 °C

6: 100 percent / NaBH₄ / ethanol / 1 h / 55 °C

7: pyridine / 14 h / 25 °C

8: p-toluenesulfonic acid / CH₂Cl₂; methanol / 1 h / 25 °C

9: 1.) POCl₃, Et₃N / 1.) THF, 0 deg C, 45 min, 2.) THF, 25 deg C, 14 h

With pyridine; hydrogenchloride; sodium tetrahydroborate; sodium hydride; toluene-4-sulfonic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00050a009

Reference yield:

: 86158-13-6
(2S)-3-(hexyloxy)-1,2-propanediol

: 1027591-49-6
3-Phenyl-thiopropionic acid S-[(R)-2-(dimethoxy-phosphoryloxy)-1-hexyloxymethyl-ethyl] ester

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / pyridine / tetrahydrofuran / 14 h / 25 °C

2: 71 percent / pyridine / CH₂Cl₂ / 14 h / 25 °C

3: 70 percent / dimethylformamide / 16 h / 80 °C

4: 100 percent / NaBH₄ / ethanol / 1 h / 55 °C

5: pyridine / 14 h / 25 °C

6: p-toluenesulfonic acid / CH₂Cl₂; methanol / 1 h / 25 °C

7: 1.) POCl₃, Et₃N / 1.) THF, 0 deg C, 45 min, 2.) THF, 25 deg C, 14 h

With pyridine; sodium tetrahydroborate; toluene-4-sulfonic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00050a009

Reference yield:

: 86158-10-3
(2S)-1-O-hexyl-2,3-O-isopropylideneglycerol

: 1027591-49-6
3-Phenyl-thiopropionic acid S-[(R)-2-(dimethoxy-phosphoryloxy)-1-hexyloxymethyl-ethyl] ester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / 1 N HCl / methanol / 24 h / 25 °C

2: 92 percent / pyridine / tetrahydrofuran / 14 h / 25 °C

3: 71 percent / pyridine / CH₂Cl₂ / 14 h / 25 °C

4: 70 percent / dimethylformamide / 16 h / 80 °C

5: 100 percent / NaBH₄ / ethanol / 1 h / 55 °C

6: pyridine / 14 h / 25 °C

7: p-toluenesulfonic acid / CH₂Cl₂; methanol / 1 h / 25 °C

8: 1.) POCl₃, Et₃N / 1.) THF, 0 deg C, 45 min, 2.) THF, 25 deg C, 14 h

With pyridine; hydrogenchloride; sodium tetrahydroborate; toluene-4-sulfonic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00050a009