(S)-2-methyl-N-((S)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide

Base Information

Chemical Name:(S)-2-methyl-N-((S)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide
CAS No.:1280655-24-4
Molecular Formula:C₁₄H₁₈F₃NO₂S
Molecular Weight:321.364
Hs Code.:

Synonyms:(S)-2-methyl-N-((S)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide

Suppliers and Price of (S)-2-methyl-N-((S)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-methyl-N-((S)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide

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Technology Process of (S)-2-methyl-N-((S)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide

There total 4 articles about (S)-2-methyl-N-((S)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1219607-83-6
(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

: 98-86-2
acetophenone

: 1280655-24-4
(S)-2-methyl-N-((S)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide

Guidance literature:: acetophenone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide; In tetrahydrofuran; at -78 ℃; for 4h; Concentration; diastereoselective reaction;
DOI:10.1016/j.jfluchem.2014.06.015

Reference yield: 43.0%

: 1219607-83-6
(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

: 1052762-47-6
lithium 1-phenylethenolate

: 1280655-24-4
(S)-2-methyl-N-((S)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide

Guidance literature:: (S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide; lithium 1-phenylethenolate; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In water; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1039/c0ob00586j

Reference yield:

: 929642-48-8,1219607-83-6
(S,E)-2-methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide

: 614-20-0
3-oxo-3-phenylpropionic acid

: (S)-2-methyl-N-((R)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide

: 1280655-24-4
(S)-2-methyl-N-((S)-1,1,1-trifluoro-4-oxo-4-phenylbutan-2-yl)propane-2-sulfinamide

Guidance literature:: With bis(acetylacetonate)nickel(II); In tetrahydrofuran; at 20 ℃; for 12h; Reagent/catalyst; Overall yield = 82 %; diastereoselective reaction;
DOI:10.1039/c5ra02653a