(S)-2-tert-Butoxycarbonylamino-3-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-propionic acid

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-3-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-propionic acid
CAS No.:261615-07-0
Molecular Formula:C₂₁H₃₀N₂O₇
Molecular Weight:422.478
Hs Code.:

Synonyms:(S)-2-tert-Butoxycarbonylamino-3-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-propionic acid

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-3-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-propionic acid

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Technology Process of (S)-2-tert-Butoxycarbonylamino-3-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-propionic acid

There total 1 articles about (S)-2-tert-Butoxycarbonylamino-3-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 223526-35-0
{(S)-2-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-1-formyl-ethyl}-carbamic acid tert-butyl ester

: 261615-07-0
(S)-2-tert-Butoxycarbonylamino-3-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-propionic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tert-butyl alcohol; at 23 ℃; for 18h;
DOI:10.1016/S0960-894X(99)00587-9

Reference yield: 71.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 261615-07-0
(S)-2-tert-Butoxycarbonylamino-3-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-propionic acid

: 261615-08-1
[(S)-2-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at -20 - 23 ℃; for 2h;
DOI:10.1016/S0960-894X(99)00587-9

Reference yield:

: 261615-07-0
(S)-2-tert-Butoxycarbonylamino-3-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-propionic acid

: (S)-3-((S)-2-Amino-3-oxo-3-pyridin-2-yl-propyl)-1-(2,4-dimethoxy-benzyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / NMM; isobutyl chloroformate / CH₂Cl₂ / 2 h / -20 - 23 °C

2: tetrahydrofuran / 4 h / -78 °C

3: HCl / dioxane / 3 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1: Condensation / 2: Arylation / 3: Acidolysis;
DOI:10.1016/S0960-894X(99)00587-9