2-O-benzyl-1-O-(p-methoxybenzyl)-3,4-O-isopropylidene-D-erythritol

Base Information

• Chemical Name: 2-O-benzyl-1-O-(p-methoxybenzyl)-3,4-O-isopropylidene-D-erythritol
• CAS No.: 1310460-69-5
• Molecular Formula: C₂₂H₂₈O₅
• Molecular Weight: 372.461
• Mol file: 1310460-69-5.mol

Synonyms:2-O-benzyl-1-O-(p-methoxybenzyl)-3,4-O-isopropylidene-D-erythritol

Chemical Property of 2-O-benzyl-1-O-(p-methoxybenzyl)-3,4-O-isopropylidene-D-erythritol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-O-benzyl-1-O-(p-methoxybenzyl)-3,4-O-isopropylidene-D-erythritol

There total 3 articles about 2-O-benzyl-1-O-(p-methoxybenzyl)-3,4-O-isopropylidene-D-erythritol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-O-benzyl-3,4-O-isopropylidene-D-erythritol (12) and 2-O-benzyl-3,4-O-isopropylidene-D-erythritol (111462-38-5) + p-methoxybenzyl chloride (824-94-2) → 2-O-benzyl-1-O-(p-methoxybenzyl)-3,4-O-isopropylidene-D-erythritol (1310460-69-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/j.bmcl.2011.02.109

Reference yield:

(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol (114184-97-3) → 2-O-benzyl-1-O-(p-methoxybenzyl)-3,4-O-isopropylidene-D-erythritol (1310460-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: di(n-butyl)tin oxide / toluene / Reflux

1.2: 60 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

With sodium hydride; di(n-butyl)tin oxide; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2011.02.109

Reference yield:

benzyl bromide (100-39-0) → 2-O-benzyl-1-O-(p-methoxybenzyl)-3,4-O-isopropylidene-D-erythritol (1310460-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: di(n-butyl)tin oxide / toluene / Reflux

1.2: 60 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

With sodium hydride; di(n-butyl)tin oxide; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2011.02.109

upstream raw materials:

(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol

benzyl bromide

1-O-benzyl-3,4-O-isopropylidene-D-erythritol ⁽¹²⁾ and 2-O-benzyl-3,4-O-isopropylidene-D-erythritol

p-methoxybenzyl chloride

Downstream raw materials:

2-O-benzyl-1-O-(p-methoxybenzyl)-D-erythritol

3,4-anhydro-2-O-benzyl-1-O-(p-methoxybenzyl)-D-erythritol