5-(1-ethylpropyl)-3-(2-hydroxyethyl)-2-(4-methoxy-2-methylphenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Base Information

Chemical Name:5-(1-ethylpropyl)-3-(2-hydroxyethyl)-2-(4-methoxy-2-methylphenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
CAS No.:1079351-96-4
Molecular Formula:C₂₂H₂₉N₃O₃
Molecular Weight:383.491
Hs Code.:

Synonyms:5-(1-ethylpropyl)-3-(2-hydroxyethyl)-2-(4-methoxy-2-methylphenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Chemical Property of 5-(1-ethylpropyl)-3-(2-hydroxyethyl)-2-(4-methoxy-2-methylphenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Technology Process of 5-(1-ethylpropyl)-3-(2-hydroxyethyl)-2-(4-methoxy-2-methylphenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

There total 6 articles about 5-(1-ethylpropyl)-3-(2-hydroxyethyl)-2-(4-methoxy-2-methylphenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52289-54-0
4-methoxysalicylaldehyde

: 1373754-04-1
C₁₃H₂₃N₃O₂

: 1079351-96-4
5-(1-ethylpropyl)-3-(2-hydroxyethyl)-2-(4-methoxy-2-methylphenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: With oxygen; In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; for 10h;
DOI:10.1016/j.bmc.2011.11.015

Reference yield:

: 2199-50-0
ethyl 5-methyl-1H-pyrrole-3-carboxylate

: 1079351-96-4
5-(1-ethylpropyl)-3-(2-hydroxyethyl)-2-(4-methoxy-2-methylphenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; diethyl ether / 30 h / 0 - 50 °C

1.2: 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 17.5 h / Reflux

3.1: tetrahydrofuran / 1 h / 0 °C

4.1: tetrahydrofuran / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

5.2: 0 °C

6.1: oxygen / 5,5-dimethyl-1,3-cyclohexadiene / 10 h / 130 °C

With lithium aluminium tetrahydride; oxygen; sodium hydride; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.11.015

Reference yield:

: C₁₂H₁₆Cl₃NO*ClH

: 1079351-96-4
5-(1-ethylpropyl)-3-(2-hydroxyethyl)-2-(4-methoxy-2-methylphenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

2.2: 0 °C

3.1: oxygen / 5,5-dimethyl-1,3-cyclohexadiene / 10 h / 130 °C

With oxygen; sodium hydride; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.11.015