4-amino-3-cyano-5-fluoro-phenacyl bromide

Base Information

• Chemical Name: 4-amino-3-cyano-5-fluoro-phenacyl bromide
• CAS No.: 83979-26-4
• Molecular Formula: C₉H₆BrFN₂O
• Molecular Weight: 257.062
• Mol file: 83979-26-4.mol

Synonyms:4-amino-3-cyano-5-fluoro-phenacyl bromide

Chemical Property of 4-amino-3-cyano-5-fluoro-phenacyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-3-cyano-5-fluoro-phenacyl bromide

There total 10 articles about 4-amino-3-cyano-5-fluoro-phenacyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-amino-3'-cyano-5'-fluoro-acetophenone (56795-45-0) → 4-amino-3-cyano-5-fluoro-phenacyl bromide (83979-26-4)

Guidance literature:

With bromine; In acetic acid; Irradiation;

Reference yield:

2-Fluoroaniline (348-54-9) → 4-amino-3-cyano-5-fluoro-phenacyl bromide (83979-26-4)

Guidance literature:

Multi-step reaction with 10 steps

1: 76 percent / I₂, NaHCO₃ / H₂O / 3 h / 60 °C

2: 88 percent / pyridine / CHCl₃ / 1.) room temp., 0.5 h, 2.) 50-60 deg C, 2 h

3: 64 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C

4: 95 percent / SnCl₂, HCl / diethyl ether; CH₂Cl₂ / 2 h

5: 1.) Mg / 1.) diethyl ether, 30 min, 2.) THF, diethyl ether, overnight, reflux

6: CrO₃, conc. H₂SO₄ / acetone; H₂O

7: 85 percent / conc. HCl / H₂O / 1 h / Heating

8: 64.4 percent / I₂, HgO / acetic acid / 1 h / Ambient temperature

9: 79 percent / dimethylformamide / 4 h / Heating

10: Br₂ / acetic acid / Irradiation

With pyridine; chromium(VI) oxide; hydrogenchloride; sulfuric acid; bromine; iodine; sodium hydrogencarbonate; magnesium; tin(ll) chloride; mercury(II) oxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide; acetone;

Reference yield:

2-fluro-4-iodoaniline (29632-74-4) → 4-amino-3-cyano-5-fluoro-phenacyl bromide (83979-26-4)

Guidance literature:

Multi-step reaction with 9 steps

1: 88 percent / pyridine / CHCl₃ / 1.) room temp., 0.5 h, 2.) 50-60 deg C, 2 h

2: 64 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C

3: 95 percent / SnCl₂, HCl / diethyl ether; CH₂Cl₂ / 2 h

4: 1.) Mg / 1.) diethyl ether, 30 min, 2.) THF, diethyl ether, overnight, reflux

5: CrO₃, conc. H₂SO₄ / acetone; H₂O

6: 85 percent / conc. HCl / H₂O / 1 h / Heating

7: 64.4 percent / I₂, HgO / acetic acid / 1 h / Ambient temperature

8: 79 percent / dimethylformamide / 4 h / Heating

9: Br₂ / acetic acid / Irradiation

With pyridine; chromium(VI) oxide; hydrogenchloride; sulfuric acid; bromine; iodine; magnesium; tin(ll) chloride; mercury(II) oxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide; acetone;

upstream raw materials:

4'-amino-3'-cyano-5'-fluoro-acetophenone

2-Fluoroaniline

2-fluro-4-iodoaniline

1-(4-amino-3-fluorophenyl)ethanone

Downstream raw materials:

4'-amino-3'-cyano-5'-fluoro-2-tert-pentylaminoacetophenone

4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone

4'-amino-2-tert-butylamino-3'-cyano-5'-fluoroacetophenone

4'-amino-3'-cyano-2-cyclopentylamino-5'-fluoroacetophenone