4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone

Base Information

• Chemical Name: 4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone
• CAS No.: 56340-27-3
• Molecular Formula: C₁₃H₁₄FN₃O
• Molecular Weight: 247.272
• Mol file: 56340-27-3.mol

Synonyms:

Chemical Property of 4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone

There total 11 articles about 4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Fluoroaniline (348-54-9) → 4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone (56340-27-3)

Guidance literature:

Multi-step reaction with 11 steps

1: 76 percent / I₂, NaHCO₃ / H₂O / 3 h / 60 °C

2: 88 percent / pyridine / CHCl₃ / 1.) room temp., 0.5 h, 2.) 50-60 deg C, 2 h

3: 64 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C

4: 95 percent / SnCl₂, HCl / diethyl ether; CH₂Cl₂ / 2 h

5: 1.) Mg / 1.) diethyl ether, 30 min, 2.) THF, diethyl ether, overnight, reflux

6: CrO₃, conc. H₂SO₄ / acetone; H₂O

7: 85 percent / conc. HCl / H₂O / 1 h / Heating

8: 64.4 percent / I₂, HgO / acetic acid / 1 h / Ambient temperature

9: 79 percent / dimethylformamide / 4 h / Heating

10: Br₂ / acetic acid / Irradiation

11: propan-2-ol

With pyridine; chromium(VI) oxide; hydrogenchloride; sulfuric acid; bromine; iodine; sodium hydrogencarbonate; magnesium; tin(ll) chloride; mercury(II) oxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

Reference yield:

2-fluro-4-iodoaniline (29632-74-4) → 4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone (56340-27-3)

Guidance literature:

Multi-step reaction with 10 steps

1: 88 percent / pyridine / CHCl₃ / 1.) room temp., 0.5 h, 2.) 50-60 deg C, 2 h

2: 64 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C

3: 95 percent / SnCl₂, HCl / diethyl ether; CH₂Cl₂ / 2 h

4: 1.) Mg / 1.) diethyl ether, 30 min, 2.) THF, diethyl ether, overnight, reflux

5: CrO₃, conc. H₂SO₄ / acetone; H₂O

6: 85 percent / conc. HCl / H₂O / 1 h / Heating

7: 64.4 percent / I₂, HgO / acetic acid / 1 h / Ambient temperature

8: 79 percent / dimethylformamide / 4 h / Heating

9: Br₂ / acetic acid / Irradiation

10: propan-2-ol

With pyridine; chromium(VI) oxide; hydrogenchloride; sulfuric acid; bromine; iodine; magnesium; tin(ll) chloride; mercury(II) oxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

Reference yield:

4'-amino-3'-cyano-5'-fluoro-acetophenone (56795-45-0) → 4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone (56340-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂ / acetic acid / Irradiation

2: propan-2-ol

With bromine; In acetic acid; isopropyl alcohol;

upstream raw materials:

cyclobutylamine

4-amino-3-cyano-5-fluoro-phenacyl bromide

2-Fluoroaniline

2-fluro-4-iodoaniline

Refernces