56795-45-0

Upstream product

• 85117-88-0 4'-acetylamino-3'-fluoro-acetophenone 
• 97760-95-7 4-acetylamino-3-fluoro-benzaldehyde 
• 93129-68-1 4-acetylamino-3-fluoro-benzonitrile 
• 97760-94-6 N-(2-fluoro-4-iodo-phenyl)-acetamide 
• 29632-74-4 2-fluro-4-iodoaniline 
• 348-54-9 2-Fluoroaniline 
• 544-92-3 copper(I) cyanide 
• 84731-71-5 4'-amino-3'-fluoro-5'-iodo-acetophenone 

Downstream Products

• 83979-26-4 4-amino-3-cyano-5-fluoro-phenacyl bromide 
• 141474-18-2 1-(4-amino-3-cyano-5-fluoro-phenyl)-2-[2-(4-methoxyphenyl)-1-methyl-ethylamino]-ethanol-hydrochloride 
• 56340-31-9 4'-amino-3'-cyano-2-cyclopentylamino-5'-fluoroacetophenone 
• 56340-27-3 4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone 
• 56340-25-1 4'-amino-3'-cyano-5'-fluoro-2-isopropylaminoacetophenone 
• 56340-23-9 4'-amino-3'-cyano-2-cyclopropylamino-5'-fluoroacetophenone 
• 56340-33-1 4'-amino-3'-cyano-5'-fluoro-2-tert-pentylaminoacetophenone 
• 56340-29-5 4'-amino-2-tert-butylamino-3'-cyano-5'-fluoroacetophenone 
• 95656-62-5 1-(4'-Amino-3'-cyano-5'-fluoro-phenyl)-2-isopropylamino-ethanol 
• 94850-93-8 1-(4'-Amino-3'-cyano-5'-fluoro-phenyl)-2-tert-butylamino-ethanol 
• 97760-51-5 2-Amino-5-(2-ethylamino-1-hydroxy-ethyl)-3-fluoro-benzonitrile 
• 56340-21-7 2-Amino-5-(2-ethylamino-acetyl)-3-fluoro-benzonitrile 

Relevant academic research and scientific papers

Process for the preparation of 3-cyano-4-aminoacetophenones

A new process is disclosed for preparing 3-cyano-4-aminoacetophenone which, starting from 3-cyano-4-acetamidoacetophenone, enables this compound to be produced on an industrial scale in high yields. 3-Cyano-4-aminoacetophenone is an intermediate product for the preparation of 2-amino-5-[1-hydroxy-2-(alkyl- or dialkyl-amino)ethyl]benzonitriles which show β2 -mimetic activities and may be used as feed additives.

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.