2-{2-fluoro-4-[2-(methylsulfinyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

Base Information

Chemical Name:2-{2-fluoro-4-[2-(methylsulfinyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole
CAS No.:1388144-42-0
Molecular Formula:C₁₉H₁₂F₄N₄OS
Molecular Weight:420.39
Hs Code.:

Synonyms:2-{2-fluoro-4-[2-(methylsulfinyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

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Chemical Property of 2-{2-fluoro-4-[2-(methylsulfinyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

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Technology Process of 2-{2-fluoro-4-[2-(methylsulfinyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

There total 4 articles about 2-{2-fluoro-4-[2-(methylsulfinyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1388144-41-9
2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

: 1388144-42-0
2-{2-fluoro-4-[2-(methylsulfinyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In ethyl acetate; at 20 ℃; for 0.5h;

Reference yield:

: 14001-67-3
5-bromo-2-methylthiopyrimidine

: 1388144-42-0
2-{2-fluoro-4-[2-(methylsulfinyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 6 h / 100 °C / Inert atmosphere; Sealed

2: sodium carbonate / 1,2-dimethoxyethane; ethanol / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

3: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / 20 °C

With potassium acetate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 1388144-42-0
2-{2-fluoro-4-[2-(methylsulfinyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; water / 0.08 h / 20 °C

1.2: 2 h / 20 °C

2.1: sodium carbonate / 1,2-dimethoxyethane; ethanol / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / 20 °C

With sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;