2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

Base Information

Chemical Name:2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole
CAS No.:1388144-41-9
Molecular Formula:C₁₉H₁₂F₄N₄S
Molecular Weight:404.391
Hs Code.:

Synonyms:2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

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Chemical Property of 2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

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Technology Process of 2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

There total 4 articles about 2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 940284-18-4
2-(methylsulfanyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

: 1356386-26-9
2-(4-bromo-2-fluorophenyl)-6-(trifluoromethyl)-1H-benzimidazole

: 1388144-41-9
2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

Guidance literature:: With sodium carbonate; In 1,2-dimethoxyethane; ethanol; at 120 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 14001-67-3
5-bromo-2-methylthiopyrimidine

: 1388144-41-9
2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 6 h / 100 °C / Inert atmosphere; Sealed

2: sodium carbonate / 1,2-dimethoxyethane; ethanol / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

With potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide;

Reference yield:

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 1388144-41-9
2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; water / 0.08 h / 20 °C

1.2: 2 h / 20 °C

2.1: sodium carbonate / 1,2-dimethoxyethane; ethanol / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

With sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;