5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole

Base Information

• Chemical Name: 5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole
• CAS No.: 1146696-25-4
• Molecular Formula: C₁₁H₆F₅NO
• Molecular Weight: 263.167
• Mol file: 1146696-25-4.mol

Synonyms:5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole

Chemical Property of 5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole

There total 1 articles about 5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,3-difluoro-4-(trifluoromethyl)benzaldehyde (134099-20-0) + 1-(toluene-4-sulfonyl)-ethyl isocyanide (58379-80-9) → 5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole (1146696-25-4)

Guidance literature:

With potassium carbonate; In methanol; for 2h; Heating / reflux;

Reference yield: 95.0%

5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole (1146696-25-4) → 2-chloro-5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole (1146696-26-5)

Guidance literature:

5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole; With lithium hexamethyldisilazane; In tetrahydrofuran; at -75 ℃; for 0.5h;

With hexachloroethane; In tetrahydrofuran; at -75 - 20 ℃;

upstream raw materials:

2,3-difluoro-4-(trifluoromethyl)benzaldehyde

1-(toluene-4-sulfonyl)-ethyl isocyanide

Downstream raw materials:

2-chloro-5-(2,3-difluoro-4-(trifluoromethyl)phenyl)-4-methyloxazole