bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[octane-1,8-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Base Information

Chemical Name:bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[octane-1,8-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate
CAS No.:1622913-97-6
Molecular Formula:C₆₀H₇₀Cl₂F₂N₈O₆
Molecular Weight:1108.17
Hs Code.:

Synonyms:bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[octane-1,8-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

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Chemical Property of bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[octane-1,8-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

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Technology Process of bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[octane-1,8-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

There total 3 articles about bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[octane-1,8-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 98560-17-9
1,8-diazidooctane

: 1622913-96-5
4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate

: 1622913-97-6
bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[octane-1,8-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; In methanol; dichloromethane; at 40 ℃; for 4h;
DOI:10.1016/j.bmcl.2014.06.079

Reference yield:

: 6089-09-4
4-pentynoic acid

: 1622913-97-6
bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[octane-1,8-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 19 h / 20 °C

3: tetrakis(actonitrile)copper(I) hexafluorophosphate / dichloromethane; methanol / 4 h / 40 °C

With oxalyl dichloride; tetrakis(actonitrile)copper(I) hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.06.079

Reference yield:

: 55183-44-3
4-pentynoic chloride

: 1622913-97-6
bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[octane-1,8-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 19 h / 20 °C

2: tetrakis(actonitrile)copper(I) hexafluorophosphate / dichloromethane; methanol / 4 h / 40 °C

With tetrakis(actonitrile)copper(I) hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.06.079