4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate

Base Information

Chemical Name:4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate
CAS No.:1622913-96-5
Molecular Formula:C₂₆H₂₇ClFNO₃
Molecular Weight:455.957
Hs Code.:

Synonyms:4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate

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Technology Process of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate

There total 2 articles about 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55183-44-3
4-pentynoic chloride

: 52-86-8
haloperidol

: 1622913-96-5
4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 19h;
DOI:10.1016/j.bmcl.2014.06.079

Reference yield:

: 6089-09-4
4-pentynoic acid

: 1622913-96-5
4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 19 h / 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2014.06.079

Reference yield: 74.0%

: 1622913-96-5
4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate

: 182760-73-2,82055-94-5
1,14-diazido-3,6,9,12-tetraoxatetradecane

: 1622914-00-4
bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; In methanol; dichloromethane; at 40 ℃; for 4h;
DOI:10.1016/j.bmcl.2014.06.079