Formic acid (R)-1-((3S,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-ethyl ester

Base Information

Chemical Name:Formic acid (R)-1-((3S,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-ethyl ester
CAS No.:106399-67-1
Molecular Formula:C₁₈H₁₇NO₃
Molecular Weight:295.338
Hs Code.:

Synonyms:Formic acid (R)-1-((3S,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Formic acid (R)-1-((3S,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-ethyl ester

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Technology Process of Formic acid (R)-1-((3S,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-ethyl ester

There total 4 articles about Formic acid (R)-1-((3S,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 64-18-6
formic acid

: 87342-69-6,87392-82-3,87419-59-8,93712-37-9,93712-38-0,93712-39-1,93712-40-4,100349-05-1,106399-66-0,106399-68-2,106399-69-3,106399-71-7,106400-00-4,113830-80-1
trans S_*-3-(1-hydroxyethyl)-1,4-diphenyl-2-azetidinone

: 93591-31-2,93713-37-2,106399-67-1,106399-70-6
Formic acid (R)-1-((3S,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-ethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; for 1.5h; Ambient temperature;
DOI:10.1016/S0040-4039(01)91165-7

Reference yield:

: 1750-36-3,33993-35-0,538-51-2,137431-97-1,137432-04-3
(E)-N-benzylidenebenzenamine

: 106399-67-1
Formic acid (R)-1-((3S,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-BuLi, N-isopropylcyclohexylamine / 1) THF, -78 deg C, 15 min, 2 , HMPA, -78 to 10 deg C

2: 1) Ph₃P, diethyl azodicarboxylate / 2) 0 to 25 deg C, 1.5 h

With n-butyllithium; N-cyclohexylisopropylamine; triphenylphosphine; diethylazodicarboxylate;
DOI:10.1021/ja00238a023

Reference yield:

: 64-18-6
formic acid

: 106399-66-0
(3S,4S)-3-((S)-1-Hydroxy-ethyl)-1,4-diphenyl-azetidin-2-one

: 106399-67-1
Formic acid (R)-1-((3S,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-ethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; Yield given. Multistep reaction; 2) 0 to 25 deg C, 1.5 h;
DOI:10.1021/ja00238a023