1,1-dicyano-2-(4-methoxybenzylamino)-2-(4-nitrophenyl)ethane

Base Information

• Chemical Name: 1,1-dicyano-2-(4-methoxybenzylamino)-2-(4-nitrophenyl)ethane
• CAS No.: 872166-86-4
• Molecular Formula: C₁₈H₁₆N₄O₃
• Molecular Weight: 336.35
• Mol file: 872166-86-4.mol

Synonyms:1,1-dicyano-2-(4-methoxybenzylamino)-2-(4-nitrophenyl)ethane

Chemical Property of 1,1-dicyano-2-(4-methoxybenzylamino)-2-(4-nitrophenyl)ethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dicyano-2-(4-methoxybenzylamino)-2-(4-nitrophenyl)ethane

There total 1 articles about 1,1-dicyano-2-(4-methoxybenzylamino)-2-(4-nitrophenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Nitrobenzylidenemalononitrile (2700-23-4) + 4-methoxy-benzylamine (2393-23-9) → 1,1-dicyano-2-(4-methoxybenzylamino)-2-(4-nitrophenyl)ethane (872166-86-4)

Guidance literature:

In acetonitrile; at 15 ℃; Further Variations:; Reaction partners; Kinetics; Product distribution; Activation energy;

DOI:10.1021/jo991823d

Reference yield:

2-bromo-1-(2,6-difluorophenyl)ethanone (56159-89-8) + 1,1-dicyano-2-(4-methoxybenzylamino)-2-(4-nitrophenyl)ethane (872166-86-4) → 4-amino-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)-2-(4-nitrophenyl)-1H-pyrrole-3-carbonitrile (872166-87-5)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 20.5h;

Reference yield:

1,1-dicyano-2-(4-methoxybenzylamino)-2-(4-nitrophenyl)ethane (872166-86-4) → 4-amino-2-[4-(cyclohexylmethylamino)-phenyl]-5-(2,6-difluorobenzoyl)-1H-pyrrole-3-carboxamide

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 20.5 h / 20 °C

2: PPA; methyl-phenyl-thioether / 4 h / 100 °C

3: iron; ammonium chloride / isopropyl alcohol / 3 h / 80 °C

4: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 12 h / 20 °C

With PPA; methyl-phenyl-thioether; sodium tris(acetoxy)borohydride; iron; potassium carbonate; ammonium chloride; acetic acid; In tetrahydrofuran; isopropyl alcohol; acetone;

upstream raw materials:

4-Nitrobenzylidenemalononitrile

4-methoxy-benzylamine

Downstream raw materials:

4-amino-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)-2-(4-nitrophenyl)-1H-pyrrole-3-carbonitrile

4-amino-2-(4-aminophenyl)-5-(2,6-difluorobenzoyl)-1H-pyrrole-3-carboxamide

4-amino-2-(4-aminophenyl)-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)-1H-pyrrole-3-carbonitrile

4-amino-2-{4-(2,6-dichlorobenzylamino)phenyl}-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)1H-pyrrole-3-carbonitrile