(+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate

Base Information

Chemical Name:(+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate
CAS No.:1450829-08-9
Molecular Formula:C₁₅H₁₈N₂O₃
Molecular Weight:274.32
Hs Code.:

Synonyms:(+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate

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Technology Process of (+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate

There total 1 articles about (+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

: 52239-91-5
4-methyl-6-phenyl-4,5-dihydropyridazin-3(2H)-one

: 105-36-2
ethyl bromoacetate

: 1450829-08-9
(+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate

Guidance literature:: With potassium carbonate; In acetonitrile; Reflux;
DOI:10.1002/chir.22162

Reference yield: 99.9%

: 1450829-08-9
(+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate

: 1450829-09-0
(+/-)-2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetic acid

Guidance literature:: (+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate; With sodium hydroxide; In water; at 80 ℃;

With hydrogenchloride; In water; Cooling;
DOI:10.1002/chir.22162

Reference yield:

: 1450829-08-9
(+/-)-ethyl 2-[5-methyl-6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl]acetate

: C₁₆H₁₈N₂O₅

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 80 °C

1.2: Cooling

2.1: triethylamine / tetrahydrofuran / 0.5 h / -5 °C

2.2: 0 °C

With triethylamine; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1002/chir.22162