(S)-N,N-bis(3-(tert-butyldimethylsilyl)-2-propyne)-2-amino-1-phenylethanol

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Chemical Name:(S)-N,N-bis(3-(tert-butyldimethylsilyl)-2-propyne)-2-amino-1-phenylethanol
CAS No.:1402063-24-4
Molecular Formula:C₂₆H₄₃NOSi₂
Molecular Weight:441.805
Hs Code.:

Synonyms:(S)-N,N-bis(3-(tert-butyldimethylsilyl)-2-propyne)-2-amino-1-phenylethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N,N-bis(3-(tert-butyldimethylsilyl)-2-propyne)-2-amino-1-phenylethanol

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Technology Process of (S)-N,N-bis(3-(tert-butyldimethylsilyl)-2-propyne)-2-amino-1-phenylethanol

There total 5 articles about (S)-N,N-bis(3-(tert-butyldimethylsilyl)-2-propyne)-2-amino-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1402063-23-3
N,N-bis(3-(tert-butyldimethylsilyl)-2-propyne)-α-aminoacetophenone

: 1402063-24-4
(S)-N,N-bis(3-(tert-butyldimethylsilyl)-2-propyne)-2-amino-1-phenylethanol

Guidance literature:: With formic acid; N-[(1S,2S)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; triethylamine; In ethyl acetate; at 28 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ol302354z DOI:10.1021/ol302354z

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1402063-24-4
(S)-N,N-bis(3-(tert-butyldimethylsilyl)-2-propyne)-2-amino-1-phenylethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 24 h / Inert atmosphere

4.1: N-[(1S,2S)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; triethylamine; formic acid / ethyl acetate / 4 h / 28 °C / Inert atmosphere

With n-butyllithium; formic acid; N-[(1S,2S)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/ol302354z DOI:10.1021/ol302354z

Reference yield:

: 1402063-22-2
1,7-bis(tert-butyldimethylsilyl)dipropargylamine

: 1402063-24-4
(S)-N,N-bis(3-(tert-butyldimethylsilyl)-2-propyne)-2-amino-1-phenylethanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 24 h / Inert atmosphere

2: N-[(1S,2S)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; triethylamine; formic acid / ethyl acetate / 4 h / 28 °C / Inert atmosphere

With formic acid; N-[(1S,2S)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; potassium carbonate; triethylamine; In ethyl acetate; acetonitrile;
DOI:10.1021/ol302354z DOI:10.1021/ol302354z