(S)-2-[4-Nitro-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

Base Information

• Chemical Name: (S)-2-[4-Nitro-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester
• CAS No.: 129175-84-4
• Molecular Formula: C₁₈H₂₀F₃N₃O₈
• Molecular Weight: 463.367

Synonyms:(S)-2-[4-Nitro-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

Chemical Property of (S)-2-[4-Nitro-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

Chemical Property:

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Technology Process of (S)-2-[4-Nitro-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

There total 2 articles about (S)-2-[4-Nitro-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-2-trifluoro-acetamido-benzoic acid (91533-09-4) → (S)-2-[4-Nitro-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester (129175-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3 h

2: Et₃N / CH₂Cl₂ / 1 h

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm00173a026

Reference yield:

diethyl-L-glutamate hydrochloride (1118-89-4) + 4-Nitro-2-(2,2,2-trifluoro-acetylamino)-benzoyl chloride → (S)-2-[4-Nitro-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester (129175-84-4)

Guidance literature:

With triethylamine; In dichloromethane; for 1h;

DOI:10.1021/jm00173a026

Reference yield:

(S)-2-[4-Nitro-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester (129175-84-4) → (S)-2-[4-Amino-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester (129175-80-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h; under 760 Torr;

DOI:10.1021/jm00173a026

upstream raw materials:

diethyl-L-glutamate hydrochloride

4-nitro-2-trifluoro-acetamido-benzoic acid

Downstream raw materials:

(S)-2-[4-Amino-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

(S)-2-[4-Methylamino-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

(S)-2-[4-Ethylamino-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

(S)-2-[4-Prop-2-ynylamino-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

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