Technology Process of C11(2)H12F3NO
There total 8 articles about C11(2)H12F3NO which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1R)-N-trifluoroacetyl-α-methylbenzylamine;
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
iodomethane-d3;
In
tetrahydrofuran;
at 20 ℃;
for 11h;
Further stages.;
DOI:10.1021/ol010108z
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 35.2 g / liquide ammonia / 14 h / 20 °C
2.1: (S)-(+)-mandelic acid / various solvent(s) / 3 h / 45 °C
2.2: 14.1 g / NaOH / H2O / 0.5 h / 20 °C
3.1: pyridine; CH2Cl2 / 2 h / 20 °C
4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C
4.2: tetrahydrofuran / 11 h / 20 °C
With
(S)-Mandelic acid; ammonia; sodium hydride;
In
tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1021/ol010108z
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 85 percent / deuterium oxide; sodium hydroxide / dioxane / 24 h / 20 °C
2.1: 56.7 g / sodium borodeuteride / methanol / 1 h / 0 °C
3.1: 70.7 g / 1 h / 20 °C
4.1: 35.2 g / liquide ammonia / 14 h / 20 °C
5.1: (S)-(+)-mandelic acid / various solvent(s) / 3 h / 45 °C
5.2: 14.1 g / NaOH / H2O / 0.5 h / 20 °C
6.1: pyridine; CH2Cl2 / 2 h / 20 °C
7.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C
7.2: tetrahydrofuran / 11 h / 20 °C
With
sodium hydroxide; sodium borodeuteride; (S)-Mandelic acid; ammonia; water-d2; sodium hydride;
In
tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane;
DOI:10.1021/ol010108z
