3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide

Base Information

• Chemical Name: 3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide
• CAS No.: 948349-73-3
• Molecular Formula: C₃₅H₄₈N₄O₇S₂
• Molecular Weight: 700.921
• Mol file: 948349-73-3.mol

Synonyms:3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide

Chemical Property of 3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide

There total 1 articles about 3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester (948349-72-2) + 2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one (138402-05-8) → 3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide (948349-73-3)

Guidance literature:

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one; With sodium hydride; In N,N-dimethyl-formamide; at -15 - 20 ℃; for 0.5h;

methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;

Reference yield:

3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide (948349-73-3) → 3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-amide

Guidance literature:

3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide; With hydrogenchloride; water; In ethanol; at 20 ℃; for 3h; Heating / reflux;

With sodium hydrogencarbonate; In water; pH=8;

upstream raw materials:

methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one