methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester

Base Information

• Chemical Name: methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester
• CAS No.: 948349-72-2
• Molecular Formula: C₂₅H₃₄N₂O₉S₃
• Molecular Weight: 602.751
• Mol file: 948349-72-2.mol

Synonyms:methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester

Chemical Property of methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester

There total 1 articles about methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-ethoxymethyl-4-hydroxymethyl-phenyl)-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)amide (948349-71-1) + methanesulfonyl chloride (124-63-0) → methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester (948349-72-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Product distribution / selectivity;

Reference yield:

methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester (948349-72-2) + 2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one (138402-05-8) → 3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide (948349-73-3)

Guidance literature:

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one; With sodium hydride; In N,N-dimethyl-formamide; at -15 - 20 ℃; for 0.5h;

methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;

Reference yield:

5,7-diethyl-[1,6]naphthyridin-2(1H)-one (146720-18-5) + methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester (948349-72-2) → 3-[4-(5,7-diethyl-2-oxo-2H-[1,6]naphthyridin-1-ylmethyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide (948350-07-0)

Guidance literature:

5,7-diethyl-[1,6]naphthyridin-2(1H)-one; With sodium hydride; In N,N-dimethyl-formamide; at -15 - 20 ℃; for 0.5h;

methanesulphonic acid 4-{2-[(4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-sulphamoyl]-5-methylthiophene-3-yl}-3-ethoxymethyl-benzyl ester; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;

upstream raw materials:

3-(2-ethoxymethyl-4-hydroxymethyl-phenyl)-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)amide

methanesulfonyl chloride

Downstream raw materials:

3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide

3-[4-(5,7-diethyl-2-oxo-2H-[1,6]naphthyridin-1-ylmethyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide

3-[4-(3-acetyl-2,6-dimethyl-pyridine-4-yloxymethyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide

3-[4-(4,6-dimethyl-3-p-tolyl-pyrazolo[4,3-c]pyridin-1-ylmethyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide