tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate

Base Information

• Chemical Name: tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate
• CAS No.: 1316309-36-0
• Molecular Formula: C₂₄H₃₄ClNO₇P₂
• Molecular Weight: 545.937
• Mol file: 1316309-36-0.mol

Synonyms:tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate

Chemical Property of tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate

There total 5 articles about tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-benzyl-C-o-chlorophenyl nitrone (22687-07-6) + 1,1-bis(diethylphosphono)ethylene (37465-31-9) → tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate (1316309-36-0)

Guidance literature:

for 0.3h; Microwave irradiation;

DOI:10.1016/j.tet.2011.05.098

Reference yield:

Tetraethyl methylenediphosphonate (1660-94-2) → tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate (1316309-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1: diethylamine / 24 h / Reflux

2: toluene-4-sulfonic acid / toluene / 24 h / Reflux

3: 0.3 h / Microwave irradiation

With toluene-4-sulfonic acid; diethylamine; In toluene;

DOI:10.1016/j.tet.2011.05.098

Reference yield:

N-benzylhydroxylamine hydrochloride (29601-98-7) → tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate (1316309-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / ethanol; water / 20 °C

2: 0.3 h / Microwave irradiation

With sodium acetate; In ethanol; water;

DOI:10.1016/j.tet.2011.05.098

upstream raw materials:

N-benzyl-C-o-chlorophenyl nitrone

1,1-bis(diethylphosphono)ethylene

Tetraethyl methylenediphosphonate

N-benzylhydroxylamine hydrochloride

Downstream raw materials:

2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonic acid