2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonic acid

Base Information

• Chemical Name: 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonic acid
• CAS No.: 1316309-43-9
• Molecular Formula: C₁₆H₁₈ClNO₇P₂
• Molecular Weight: 433.722
• Mol file: 1316309-43-9.mol

Synonyms:2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonic acid

Chemical Property of 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonic acid

There total 4 articles about 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate (1316309-36-0) → 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonic acid (1316309-43-9)

Guidance literature:

tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate; With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 72h;

With methanol; for 1h;

DOI:10.1016/j.tet.2011.05.098

Reference yield:

N-benzyl-C-o-chlorophenyl nitrone (22687-07-6) → 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonic acid (1316309-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 0.3 h / Microwave irradiation

2.1: trimethylsilyl bromide / dichloromethane / 72 h / 20 °C

2.2: 1 h

With trimethylsilyl bromide; In dichloromethane;

DOI:10.1016/j.tet.2011.05.098

Reference yield:

N-benzylhydroxylamine hydrochloride (29601-98-7) → 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonic acid (1316309-43-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium acetate / ethanol; water / 20 °C

2.1: 0.3 h / Microwave irradiation

3.1: trimethylsilyl bromide / dichloromethane / 72 h / 20 °C

3.2: 1 h

With trimethylsilyl bromide; sodium acetate; In ethanol; dichloromethane; water;

DOI:10.1016/j.tet.2011.05.098

upstream raw materials:

tetraethyl 2-benzyl-3-o-chloro-phenyl-isoxazolidine-5,5-diyl-bisphosphonate

N-benzyl-C-o-chlorophenyl nitrone

N-benzylhydroxylamine hydrochloride

2-chloro-benzaldehyde