2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

Base Information

• Chemical Name: 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine
• CAS No.: 256219-19-9
• Molecular Formula: C₂₇H₃₇F₂N₃O₅S
• Molecular Weight: 553.671
• Mol file: 256219-19-9.mol

Synonyms:2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

Chemical Property of 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine

There total 7 articles about 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,2-dimethyl-1-methylpropylamine (3850-30-4) + 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine (256219-16-6) → 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine (256219-19-9)

Guidance literature:

In ethanol; at 20 ℃;

DOI:10.1021/jm990443h

Reference yield:

ethyl acetoacetate (141-97-9) → 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine (256219-19-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / ethanol / 8 h / Heating

2: 87 percent / Raney nickel; H₂ / ethanol / 6 h / 50 - 55 °C

3: 66 percent / CH₂Cl₂ / 2 h / Heating

4: 92 percent / ethanol / 20 °C

With hydrogen; nickel; In ethanol; dichloromethane; 1: Cyclization / 2: Reduction / 3: thiophosgenation / 4: Addition;

DOI:10.1021/jm990443h

Reference yield:

o-difluoromethoxybenzaldehyde (71653-64-0) → 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-N-(N'-1,2,2-trimethylpropylthiouredyl)phenyl)-1,4-dihydroxypyridine (256219-19-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / H₂SO₄; fumic nitric acid / 1 h / 20 °C

2: 78 percent / ethanol / 8 h / Heating

3: 87 percent / Raney nickel; H₂ / ethanol / 6 h / 50 - 55 °C

4: 66 percent / CH₂Cl₂ / 2 h / Heating

5: 92 percent / ethanol / 20 °C

With sulfuric acid; hydrogen; nitric acid; nickel; In ethanol; dichloromethane; 1: Nitration / 2: Cyclization / 3: Reduction / 4: thiophosgenation / 5: Addition;

DOI:10.1021/jm990443h

upstream raw materials:

2,2-dimethyl-1-methylpropylamine

2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

ethyl acetoacetate

o-difluoromethoxybenzaldehyde

Downstream raw materials:

4-[2-difluoromethoxy-5-(1,2,2-trimethyl-propyliminomethyleneamino)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester