2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

Base Information

Chemical Name:2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine
CAS No.:256219-16-6
Molecular Formula:C₂₁H₂₂F₂N₂O₅S
Molecular Weight:452.479
Hs Code.:

Synonyms:2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

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Chemical Property of 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

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Technology Process of 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

There total 6 articles about 2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 88-11-9
N,N-diethylthiocarbamoyl chloride

: 256219-14-4
2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-aminophenyl)-1,4-dihydropyridine

: 256219-16-6
2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

Guidance literature:: In dichloromethane; for 2h; Heating;
DOI:10.1021/jm990443h

Reference yield:

: 71653-64-0
o-difluoromethoxybenzaldehyde

: 256219-16-6
2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂SO₄; fumic nitric acid / 1 h / 20 °C

2: 78 percent / ethanol / 8 h / Heating

3: 87 percent / Raney nickel; H₂ / ethanol / 6 h / 50 - 55 °C

4: 66 percent / CH₂Cl₂ / 2 h / Heating

With sulfuric acid; hydrogen; nitric acid; nickel; In ethanol; dichloromethane; 1: Nitration / 2: Cyclization / 3: Reduction / 4: thiophosgenation;
DOI:10.1021/jm990443h

Reference yield:

: 141-97-9
ethyl acetoacetate

: 256219-16-6
2,6-dimethyl-3,5-dicarboethoxy-4-(2-difluoromethoxy-5-isothiocyanatophenyl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / ethanol / 8 h / Heating

2: 87 percent / Raney nickel; H₂ / ethanol / 6 h / 50 - 55 °C

3: 66 percent / CH₂Cl₂ / 2 h / Heating

With hydrogen; nickel; In ethanol; dichloromethane; 1: Cyclization / 2: Reduction / 3: thiophosgenation;
DOI:10.1021/jm990443h