3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'{[N-(3'-deoxythymidine-3'-yl)carboxamido]methyl}ribosylthymine

Base Information

Chemical Name:3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'{[N-(3'-deoxythymidine-3'-yl)carboxamido]methyl}ribosylthymine
CAS No.:1232359-48-6
Molecular Formula:C₃₅H₄₉N₅O₁₀Si
Molecular Weight:727.887
Hs Code.:

Synonyms:3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'{[N-(3'-deoxythymidine-3'-yl)carboxamido]methyl}ribosylthymine

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Chemical Property of 3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'{[N-(3'-deoxythymidine-3'-yl)carboxamido]methyl}ribosylthymine

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Technology Process of 3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'{[N-(3'-deoxythymidine-3'-yl)carboxamido]methyl}ribosylthymine

There total 9 articles about 3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'{[N-(3'-deoxythymidine-3'-yl)carboxamido]methyl}ribosylthymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1232359-45-3
3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-{[N-(5'-O-tert-butyldimethylsilyl-3'-deoxythymidine-3'-yl)carboxamido]methyl}ribosylthymine

: 1232359-48-6
3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'{[N-(3'-deoxythymidine-3'-yl)carboxamido]methyl}ribosylthymine

Guidance literature:: With trifluoroacetic acid; In water; at 0 ℃; for 0.333333h;
DOI:10.1134/S1068162010020093

Reference yield:

: 1232359-36-2
3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine

: 1232359-48-6
3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'{[N-(3'-deoxythymidine-3'-yl)carboxamido]methyl}ribosylthymine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 1 h

2: 1,1'-carbonyldiimidazole / dichloromethane / 1 h

3: trifluoroacetic acid / water / 0.33 h / 0 °C

With 1,1'-carbonyldiimidazole; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1134/S1068162010020093

Reference yield:

: 1232359-39-5
3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-carboxymethylribosylthymine

: 1232359-48-6
3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'{[N-(3'-deoxythymidine-3'-yl)carboxamido]methyl}ribosylthymine

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h

2: trifluoroacetic acid / water / 0.33 h / 0 °C

With 1,1'-carbonyldiimidazole; trifluoroacetic acid; In dichloromethane; water;
DOI:10.1134/S1068162010020093