Ribociclib intermediate

Base Information

• Chemical Name: Ribociclib intermediate
• CAS No.: 1211443-55-8
• Molecular Formula: C₁₂H₁₂ClN₃O
• Molecular Weight: 249.7
• Hs Code.: 2933998090
• Mol file: 1211443-55-8.mol

Synonyms:2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde

Chemical Property of Ribociclib intermediate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Pyrrolo[2,3-d]pyrimidine compounds, regarded as an important class of N-heterocycles, have played a significant role in medicinal chemistry and material chemistry.

Technology Process of Ribociclib intermediate

There total 1 articles about Ribociclib intermediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol (1374639-77-6) → 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde (1211443-55-8)

Guidance literature:

With manganese(IV) oxide; In tetrahydrofuran; at 10 - 29 ℃; for 2h; Inert atmosphere;

DOI:10.2174/1386207320666170816141351

Reference yield:

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde (1211443-55-8) + aniline (62-53-3) → (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-ylmethylene)phenylamine

Guidance literature:

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde; aniline; With silica gel; In acetone; for 0.166667h;

for 0.0333333h; Microwave irradiation;

DOI:10.2174/1386207320666170816141351

Reference yield:

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde (1211443-55-8) + 4-bromo-aniline (106-40-1) → (4-bromo-phenyl)-(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-ylmethylene)amine

Guidance literature:

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde; 4-bromo-aniline; With silica gel; In acetone; for 0.166667h;

for 0.0333333h; Microwave irradiation;

DOI:10.2174/1386207320666170816141351

upstream raw materials:

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol