4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Name:4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1346175-13-0
Molecular Formula:C₃₀H₂₄FN₅O₃S
Molecular Weight:553.617
Hs Code.:

Synonyms:4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

There total 4 articles about 4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 479633-63-1
4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

: 1213269-68-1
4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazole

: 1346175-13-0
4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: 4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With tributyltin chloride; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h; Inert atmosphere;

4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine; With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 4h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2011.09.053

Reference yield:

: 403-32-7
(4-fluorophenyl)glyoxal

: 1346175-13-0
4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate / methanol / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h

2.2: 0.5 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 - 20 °C / Inert atmosphere

3.3: 4 h / Inert atmosphere; Reflux

With n-butyllithium; ammonium acetate; sodium hydride; In tetrahydrofuran; methanol; 3.3: Stille coupling;
DOI:10.1016/j.tet.2011.09.053

Reference yield:

: 100-52-7
benzaldehyde

: 1346175-13-0
4-[4-(4-fluorophenyl)-1-(methoxymethyl)-2-phenyl-1H-imidazol-5-yl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate / methanol / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h

2.2: 0.5 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 - 20 °C / Inert atmosphere

3.3: 4 h / Inert atmosphere; Reflux

With n-butyllithium; ammonium acetate; sodium hydride; In tetrahydrofuran; methanol; 3.3: Stille coupling;
DOI:10.1016/j.tet.2011.09.053