(+/-)-1-(5-ethyl-2-hydroxy-2-methyl-5-nitrocyclohexyl)-1-ethanone

Base Information

• Chemical Name: (+/-)-1-(5-ethyl-2-hydroxy-2-methyl-5-nitrocyclohexyl)-1-ethanone
• CAS No.: 100401-24-9
• Molecular Formula: C₁₁H₁₉NO₄
• Molecular Weight: 229.276
• Mol file: 100401-24-9.mol

Synonyms:(+/-)-1-(5-ethyl-2-hydroxy-2-methyl-5-nitrocyclohexyl)-1-ethanone

Chemical Property of (+/-)-1-(5-ethyl-2-hydroxy-2-methyl-5-nitrocyclohexyl)-1-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-1-(5-ethyl-2-hydroxy-2-methyl-5-nitrocyclohexyl)-1-ethanone

There total 3 articles about (+/-)-1-(5-ethyl-2-hydroxy-2-methyl-5-nitrocyclohexyl)-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl vinyl ketone (78-94-4,25038-87-3) + 1-Nitropropane (108-03-2) → (+/-)-1-(5-ethyl-2-hydroxy-2-methyl-5-nitrocyclohexyl)-1-ethanone (100401-24-9)

Guidance literature:

With potassium carbonate; In water; at 20 ℃; for 24h;

DOI:10.1021/jo0006324

Reference yield:

methyl vinyl ketone (78-94-4,25038-87-3) + 1-Nitropropane (108-03-2) → (+/-)-1-(5-ethyl-2-hydroxy-2-methyl-5-nitrocyclohexyl)-1-ethanone (100401-24-9) + (+/-)-1-[(1S,2R,5R)-5-ethyl-2-hydroxy-2-methyl-5-nitrocyclohexyl]-1-ethanone

Guidance literature:

With potassium carbonate; In water; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(00)00324-0

Reference yield:

methyl vinyl ketone (78-94-4,25038-87-3) + 1-Nitropropane (108-03-2) → 5-nitroheptan-2-one (42397-25-1) + (+/-)-1-(5-ethyl-2-hydroxy-2-methyl-5-nitrocyclohexyl)-1-ethanone (100401-24-9)

Guidance literature:

With poly(propyleneimine) 5th generation dendrimer functionalized with C₁₆ alkyl chain; In toluene; at 70 ℃; for 48h; Inert atmosphere;

DOI:10.1246/cl.2012.801

upstream raw materials:

methyl vinyl ketone

1-Nitropropane

Downstream raw materials:

1-(5-ethyl-2-methylphenyl)-1-ethanone

1-Methyl-2-acetyl-4-aethyl-4-nitro-cyclohexen-⁽¹⁾