(S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt

Base Information

Chemical Name:(S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt
CAS No.:1541197-63-0
Molecular Formula:C₁₇H₂₅BrN₂O₃*ClH
Molecular Weight:421.762
Hs Code.:

Synonyms:(S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt

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Chemical Property of (S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt

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Technology Process of (S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt

There total 7 articles about (S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

: 1541197-73-2
(S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester

: 1541197-63-0
(S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 4h; Reflux;

Reference yield:

: 129316-09-2
1,3-dibromo-5-t-butylbenzene

: 1541197-63-0
(S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: ammonium acetate / isopropyl alcohol / 14 h / Reflux; Inert atmosphere

3.1: hydrogenchloride / 1.5 h / Reflux

4.1: water; sodium hydroxide

4.2: 20 °C / pH 8.2 / Enzymatic reaction

5.1: hydrogenchloride / 2 h / Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 4 h / Reflux

With hydrogenchloride; n-butyllithium; ammonium acetate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; diethyl ether; hexane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 241155-85-1
3-bromo-5-formyl-tert-butylbenzene

: 1541197-63-0
(S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate / isopropyl alcohol / 14 h / Reflux; Inert atmosphere

2.1: hydrogenchloride / 1.5 h / Reflux

3.1: water; sodium hydroxide

3.2: 20 °C / pH 8.2 / Enzymatic reaction

4.1: hydrogenchloride / 2 h / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane / 4 h / Reflux

With hydrogenchloride; ammonium acetate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol;