Heptakis(2,3-di-O-methyl)-6^B,6^C,6^D,6^E,6^F,6^G-hexa-O-methyl-6^A-O-(toluenesulfonyl)-β-cyclodextrin

Base Information

• Chemical Name: Heptakis(2,3-di-O-methyl)-6^B,6^C,6^D,6^E,6^F,6^G-hexa-O-methyl-6^A-O-(toluenesulfonyl)-β-cyclodextrin
• CAS No.: 94789-63-6
• Molecular Formula: C₆₉H₁₁₆O₃₇S
• Molecular Weight: 1569.72
• Mol file: 94789-63-6.mol

Synonyms:Heptakis(2,3-di-O-methyl)-6^B,6^C,6^D,6^E,6^F,6^G-hexa-O-methyl-6^A-O-(toluenesulfonyl)-β-cyclodextrin

Chemical Property of Heptakis(2,3-di-O-methyl)-6^B,6^C,6^D,6^E,6^F,6^G-hexa-O-methyl-6^A-O-(toluenesulfonyl)-β-cyclodextrin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Heptakis(2,3-di-O-methyl)-6^B,6^C,6^D,6^E,6^F,6^G-hexa-O-methyl-6^A-O-(toluenesulfonyl)-β-cyclodextrin

There total 4 articles about Heptakis(2,3-di-O-methyl)-6^B,6^C,6^D,6^E,6^F,6^G-hexa-O-methyl-6^A-O-(toluenesulfonyl)-β-cyclodextrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-monohydroxy permethylated β-cyclodextrin (94789-61-4) + p-toluenesulfonyl chloride (98-59-9) → Heptakis(2,3-di-O-methyl)-6B,6C,6D,6E,6F,6G-hexa-O-methyl-6A-O-(toluenesulfonyl)-β-cyclodextrin (94789-63-6)

Guidance literature:

6-monohydroxy permethylated β-cyclodextrin; With n-butyllithium; In tetrahydrofuran; hexane; at -15 ℃; for 0.333333h;

p-toluenesulfonyl chloride; In tetrahydrofuran; hexane; at -15 ℃; for 0.75h;

DOI:10.1002/chem.201100621

Reference yield: 93.0%

heptakis(2,3-di-O-methyl)-6I-O-p-tolylsulfonyl-cyclomaltoheptaose (166305-90-4) + methyl trifluoromethanesulfonate (333-27-7) → Heptakis(2,3-di-O-methyl)-6B,6C,6D,6E,6F,6G-hexa-O-methyl-6A-O-(toluenesulfonyl)-β-cyclodextrin (94789-63-6)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; at 80 ℃; for 2.5h;

DOI:10.1021/jo00070a019

Reference yield: 88.0%

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin (67217-55-4) + methyl iodide (74-88-4) → Heptakis(2,3-di-O-methyl)-6B,6C,6D,6E,6F,6G-hexa-O-methyl-6A-O-(toluenesulfonyl)-β-cyclodextrin (94789-63-6)

Guidance literature:

With sodium hydride;

DOI:10.1002/cctc.201901658

upstream raw materials:

heptakis(2,3-di-O-methyl)-6^I-O-p-tolylsulfonyl-cyclomaltoheptaose

methyl trifluoromethanesulfonate

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin

methyl iodide

Downstream raw materials:

6A-deoxy-6A-diphenylphosphinyl-2A,2B,2C,2D,2E,2F,2G,3A,3B,3C,3D,3E,3F,3G,6B,6C,6D,6E,6F,6G-eicosa-O-methyl-β-cyclodextrin

6(A)-O-[4-(diphenylphosphino)phenyl]-2(A),2(B),2(C),2(D),2(E),2(F),2(G),3(B),3(C),3(D),3(E),3(F),3(G),6(B),6(C),6(D),6(E),6(F),6(G)-eicosa-O-methyl-β-cyclodextrin