Technology Process of N-(1-benzyl-4-hydroxymethyl-piperidin-4-yl)-2-chloro-acetamide
There total 4 articles about N-(1-benzyl-4-hydroxymethyl-piperidin-4-yl)-2-chloro-acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
dichloromethane; water;
at 0 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 19 - 29 °C / Cooling
1.2: 8 - 56 °C
2.1: dichloromethane; water / 0.58 h / Cooling with ice
With
lithium aluminium tetrahydride;
In
tetrahydrofuran; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: water; methanol / Cooling with ice
1.2: 72 h / 20 °C / Cooling with ice
2.1: sodium hydroxide; water / 80 - 108 °C / Industry scale
2.2: 10 - 23 °C / pH 7 - 8 / Industry scale
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 19 - 29 °C / Cooling
3.2: 8 - 56 °C
4.1: dichloromethane; water / 0.58 h / Cooling with ice
With
lithium aluminium tetrahydride; water; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;